Rx MOTS-c

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MOTS-c peptide references

Every quantitative claim on this site maps to a numbered entry below. Primary studies and reviews, with DOIs and PubMed identifiers.

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Citations are numbered in the order they first appear across the site. Primary experimental studies in mice, cells, and human cohorts are listed alongside the reviews that frame them. Where a study is observational — the human serum-biomarker work — that is noted on the relevant page rather than restated here. Full citation detail for each entry — authors, journal, year, volume, pages, DOI, and PubMed URL — follows in the research references list below.

  1. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-454. ↗
  2. Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470. ↗
  3. Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018;28(3):516-524.e7. ↗
  4. Wan W, Zhang L, Lin Y, Rao X, Wang X, Hua F, Ying J. Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging. J Transl Med. 2023;21(1):36. ↗
  5. Jiang J, Chang X, Nie Y, et al. Peripheral Administration of a Cell-Penetrating MOTS-c Analogue Enhances Memory and Attenuates Abeta1-42- or LPS-Induced Memory Impairment through Inhibiting Neuroinflammation. ACS Chem Neurosci. 2021;12(8):1506-1518. ↗
  6. Tekin S, Bir LS, Avci E, et al. Comparison of Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Levels in Patients With Multiple Sclerosis and Healthy Controls. Cureus. 2022;14(7):e26981. ↗
  7. Alser M, Ramanjaneya M, Anwardeen NR, Donati F, Botre F, Jerobin J, Bettahi I, Mohamed NA, Abou-Samra AB, Elrayess MA. The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes. Rev Cardiovasc Med. 2022;23(5):181. ↗
  8. Kong BS, Lee C, Cho YM. Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases. Diabetes Metab J. 2023;47(3):315-324. ↗
  9. Luo YH, Xie L, Li JY, Xie Y, Li MQ, Zhou L. Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function. Diabetes Metab Syndr Obes. 2023;16:1125-1133. ↗
  10. Gao Y, Wei X, Wei P, Lu H, Zhong L, Tan J, Liu H, Liu Z. MOTS-c Functionally Prevents Metabolic Disorders. Metabolites. 2023;13(1):125. ↗
  11. Domin R, Pytka M, Ruchala M. MOTS-c Serum Concentration Positively Correlates with Lower-Body Muscle Strength and Is Not Related to Maximal Oxygen Uptake - A Preliminary Study. Int J Mol Sci. 2023;24(19):14951. ↗
  12. Lee C. Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c. Mol Cell Oncol. 2019;6(2):e1549464. ↗
  13. Kumagai H, Kim SJ, Miller B, et al. MOTS-c modulates skeletal muscle function by directly binding and activating CK2. iScience. 2024;27(11):111212. ↗
  14. Bolignano D, Greco M, Presta P, Duni A, et al. The Mitochondrial-Derived Peptide MOTS-c May Refine Mortality and Cardiovascular Risk Prediction in Chronic Hemodialysis Patients: A Multicenter Cohort Study. Blood Purif. 2024;53(10):824-837. ↗